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AZD4547 Chemical Structure

AZD4547

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02555CAS No. :1035270-39-3Purity:98%
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  • Publications Citing of Biochempartner's AZD4547
  • Chemical Properties&Biological Activity
CAS No. 1035270-39-3 Cat. No. BCP02555
Name AZD4547
Synonyms AZD 4547;AZD-4547;
SMILES
Chemical Name
Formula C26H33N5O3 M. Wt 463.57
Purity 98% Storage Store at 4-8°C
Description Compared to FGFR1-3, AZD4547 displays weaker activity against FGFR4 with IC50 of 165 nM. AZD4547 only inhibits recombinant VEGFR2 (KDR) kinase activity with IC50 of 24 nM, in the in vitro selectivity test against a diverse panel of representative human kinases. AZD4547 at 0.1 μM exhibits no activity against a range of recombinant kinases including ALK, CHK1, EGFR, MAPK1, MEK1, p70S6K, PDGFR, PKB, Src, Tie2, and PI3-kinase. Consistently, the potent selectivity of AZD4547 for FGFR1-3 over FGFR4, IGFR, and KDR is also observed in cellular phosphorylation assays. AZD4547 has potent in vitro antiproliferative activity only against tumor cell lines expressing deregulated FGFRs such as KG1a, Sum52-PE, and KMS11 with IC50 of 18-281 nM, and is inactive against MCF7 as well as more than 100 additional tumor cell lines. AZD4547 treatment potently inhibits FGFR and MAPK phosphorylation in human tumor cell lines in a dose-dependent manner. AZD4547 also potently inhibits the phosphorylation of FRS2
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