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Dolutegravir Chemical Structure

Dolutegravir

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02329CAS No. :1051375-16-6Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 1051375-16-6 Cat. No. BCP02329
Name Dolutegravir
Synonyms GSK1349572;GSK 1349572;GSK-1349572;S/GSK1349572;S-349572;
SMILES FC1=CC(F)=C(C=C1)CNC(C2=CN(C3=C(C2=O)O)C[C@@]([H])(N4C3=O)OCC[C@]4C)=O
Chemical Name
Formula C20H19F2N3O5 M. Wt 419.38
Purity 98% Storage Store at 4-8°C
Description Dolutegravir is an orally bioavailable integrase strand-transfer inhibitor (INSTI), with activity against human immunodeficiency virus type 1 (HIV-1) infection. Upon oral administration, dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This prevents HIV-1 replication.
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