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NSC 133723 Chemical Structure

NSC 133723

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02884CAS No. :19741-14-1Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 19741-14-1 Cat. No. BCP02884
Name NSC 133723
Synonyms NSC131463;DAMPA;NSC-131463;Deoxyaminopteroic acid;Methotrexate Impurity E;4-Amino-4-deoxy-10-methylpteroic acid;
SMILES O=C(O)C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1
Chemical Name
Formula C15H15N7O2 M. Wt 325.33
Purity 98% Storage Store at 4-8°C
Description NSC 131463 is a minor metabolite of methotrexate. It inhibited L1210 cell proliferation in culture (IC50 = 0.3 μM), and prolonged the survival of L1210 leukemic mice (98% increase in lifespan at 120 mg/kg, qdx9). Studies on the interaction of mAPA-HCysA with partially purified mouse liver folyl polyglutamate synthetase revealed that mAPA-HCysA was not a substrate. Hence, the increased dose of mAPA-HCysA required to inhibit tumor growth in vitro and in vivo relative to methotrexate may reflect, in part, the inability of this compound to form non-effluxing polyglutamates.
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