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APR-246 Chemical Structure

APR-246

Data Sheet For research use only. Not for human use.
Cat. No. :BCP20294CAS No. :5291-32-7Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 5291-32-7 Cat. No. BCP20294
Name APR-246
Synonyms APR 246;APR246;Prima-1met;
SMILES
Chemical Name
Formula C10H17NO3 M. Wt 199
Purity 98% Storage Store at 4-8°C
Description APR-246 is a quinuclidinone derivative that targets the Wrap53 gene with potential antineoplastic activity. p53 activator APR-246 binds to and activates transcription of the Wrap53 gene, which results in an increase in WRAP53 p53 antisense transcript levels and, potentially, an increase in native p53 activity; in turn, increased p53 activity may lead to an induction of cell cycle arrest and apoptosis in tumor cells. This agent may work synergistically with other antineoplastic agents.
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