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PRI-724 Chemical Structure

PRI-724

Data Sheet For research use only. Not for human use.
Cat. No. :BCP02465CAS No. :847591-62-2Purity:98%
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  • Chemical Properties&Biological Activity
CAS No. 847591-62-2 Cat. No. BCP02465
Name PRI-724
Synonyms PRI724; PRI 724; ICG001 isomer; ICG-001 isomer; ICG 001 isomer;
SMILES C1CN(C2CN(C(=O)C(N2C1=O)CC3=CC=C(C=C3)O)CC4=CC=CC5=CC=CC=C54)C(=O)NCC6=CC=CC=C6
Chemical Name
Formula C33H32N4O4 M. Wt 548.63
Purity 98% Storage Store at 4-8°C
Description PRI-724, an isomer or enantiomer of ICG-001, is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. Note: ICG-001 and PRR-724 are not the same molecule, which are enantiomer isomers. Many vendors confused them.
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