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Angiogenesis/Protein Tyrosine Kinase

Chemical Structure Cat. No. Product Name CAS No.
Carotegrast Chemical Structure
BCP40366 Carotegrast 401904-75-4
Carotegrast is an anti-inflammatory agent.
DS-1206b Chemical Structure
BCP40272 DS-1206b 1855860-24-0
DS-1206b is a selective and potent AXL kinase inhibitor with IC50 of 1.3?nM.
XL-092 Chemical Structure
BCP40284 XL-092 2367004-54-2
XL092 is an investigational, next-generation oral TKI that targets VEGF receptors, MET, AXL, MER and other kinases implicated in the growth and spread of cancer.
SRX3207 Chemical Structure
BCP40266 SRX3207 2254693-15-5
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively.
Carotegrast methyl Chemical Structure
BCP40218 Carotegrast methyl 401905-67-7
Carotegrast methyl is an orally-active small molecule that antagonises the α4 integrin receptor.
Enarodustat Chemical Structure
BCP39690 Enarodustat 1262132-81-9
Enarodustat (JTZ-951) exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition.
AST5902 Chemical Structure
BCP39664 AST5902 AST5902
Alflutinib is mainly metabolized via CYP3A4 to form its active metabolite AST5902.
KX2-391 Mesylate Chemical Structure
BCP25173 KX2-391 Mesylate 1080645-95-9
Tirbanibulin, also known as KX-01 and KX2-391, is the first clinical Src inhibitor of the novel peptidomimetic class that targets the peptide substrate site of Src providing more specificity toward Src kinase.
HIF-2a Translation Inhibitor 76 Chemical Structure
BCP38668 HIF-2a Translation Inhibitor 76 882268-69-1
HIF-2a Translation Inhibitor 76 is a cell-permeable HIF-2a translation inhibitor (IC50 value 5 μM).
JND3229 Chemical Structure
BCP38649 JND3229 2260886-64-2
JND3229 is a New EGFRC797S Mutant Inhibitor with In Vivo Monodrug Efficacy (IC50 = 5.8 nM).
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