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Apoptosis Pathway

Chemical Structure Cat. No. Product Name CAS No.
Mcl1-IN-2 Chemical Structure
BCP40301 Mcl1-IN-2 292057-76-2
Mcl1-IN-2, a hydroxyquinoline derivative, is an Mcl-1 inhibitor.
APG-2575 Chemical Structure
BCP40069 APG-2575 APG2575
APG-2575 is a novel, orally administered small-molecule Bcl-2?selective inhibitor.
EN4 Chemical Structure
BCP40015 EN4 1197824-15-9
EN4 is a functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC.
BDA-366 Chemical Structure
BCP39785 BDA-366 1909226-00-1
BDA-366 is a small-molecule Bcl2-BH4 domain antagonist, BDA-366, that binds BH4 with high affinity and selectivity.
RO-5963 Chemical Structure
BCP39170 RO-5963 1416663-77-8
RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53.
S55746 Chemical Structure
BCP39114 S55746 1448584-12-0
S55746 is an orally available BCL-2 specific inhibitor (Ki = 1.3 nM), displaying 70 to 400-fold selectivity for BCL-2 over BCL-XL.
INCB086550 Chemical Structure
BCP38993 INCB086550 INCB086550
INCB086550, a first-in-class oral inhibitor of PD-L1, as initial immune checkpoint inhibitor therapy in participants with select solid tumors
GSK-963 Chemical Structure
BCP37994 GSK-963 2049868-46-2
GSK-963 is a potent and selective inhibitor of RIP1 kinase.
GSK962 Chemical Structure
BCP37995 GSK962 2049872-86-6
GSK962 is a negative control for GSK'963, a highly potent and selective RIP1 inhibitor.
GSK-843 Chemical Structure
BCP37845 GSK-843 1601496-05-2
GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM.
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