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Autophagy

Chemical Structure Cat. No. Product Name CAS No.
PHY34 Chemical Structure
BCP39986 PHY34 2130033-55-3
PHY34 is a potent autophagy inhibitor with cytotoxic effects by inhibiting autophagy at a late stage (MDA-MB-435 IC50=23 nM, MDA-MB-231 IC50=5.2 nM).
ULK-101 Chemical Structure
BCP37780 ULK-101 2443816-45-1?
ULK-101 is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM.
SR9011 Chemical Structure
BCP37352 SR9011 1379686-29-9
SR9011 is a REV-ERBα/β agonist with IC50s of 790 nM and 560 nM for REV-ERBα and REV-ERBβ, respectively.
Vacuolin-1 Chemical Structure
BCP35743 Vacuolin-1 351986-85-1
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.
Urolithin A Chemical Structure
BCP35737 Urolithin A 1143-70-0
Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis.
YM-155 hydrochloride Chemical Structure
BCP35549 YM-155 hydrochloride 355406-09-6
YM155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
Procainamide methacrylamide Chemical Structure
BCP35472 Procainamide methacrylamide 78723-47-4
KN92 Chemical Structure
BCP35203 KN92 176708-42-2
KN-92 is an inactive derivative of KN-93.
Autogramin-1 Chemical Structure
BCP35150 Autogramin-1 2375541-73-2
Autogramin-1 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).
Amiodarone Chemical Structure
BCP35085 Amiodarone 1951-25-3
Amiodarone is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with an IC50 of 19.1 μM.
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