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FXR

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FXR

Chemical Structure Cat. No. Product Name CAS No.
EDP-305 Chemical Structure
BCP40718 EDP-305 1933507-63-1
EDP-305 is a novel and potent farnesoid X receptor (FXR) agonist, with no/minimal cross-reactivity to TGR5 or other nuclear receptors.
(Z)-Guggulsterone Chemical Structure
BCP07472 (Z)-Guggulsterone 39025-23-5
Z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.
Vonafexor Chemical Structure
BCP33693 Vonafexor 1192171-69-9
Vonafexor is a farnesoid X receptor agonist.
LY2562175 Chemical Structure
BCP33226 LY2562175 1103500-20-4
LY2562175 is a potent and selective FXR agonist with an EC50 of 193 nM.
Sevelamer hydrochloride Chemical Structure
BCP21176 Sevelamer hydrochloride 152751-57-0
Sevelamer Hcl is a phosphate binding drug used to treat hyperphosphatemia in patients with chronic kidney disease; consists of polyallylamine that is crosslinked with epichlorohydrin.
Nidufexor Chemical Structure
BCP28929 Nidufexor 1773489-72-7
Nidufexor is a farnesoid X receptor (FXR) agonist.
Cilofexor Chemical Structure
BCP29283 Cilofexor 1418274-28-8
Cilofexor is a farnesoid X receptor (FXR) agonist.
GW4064 Chemical Structure
BCP22751 GW4064 278779-30-9
GW 4064 is a potent FXR agonist with EC50 of 65 nM.
BAR502 Chemical Structure
BCP19638 BAR502 1612191-86-2
BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.
Chenodeoxycholic acid Chemical Structure
BCP09679 Chenodeoxycholic acid 474-25-9
Chenodeoxycholic Acid is a hydrophobic primary bile acid that activates nuclear receptors (FXR) involved in cholesterol metabolism.
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