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PARP

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PARP

Chemical Structure Cat. No. Product Name CAS No.
Fuzuopali Chemical Structure
BCP38585 Fuzuopali 1358715-18-0
Fluzoparib is a selective poly [ADP-ribose] polymerase 1 (PARP1) and poly [ADP-ribose] polymerase 2 inhibitor (PARP2).
TFLLR-NH2 Chemical Structure
BCP38224 TFLLR-NH2 197794-83-5
TFLLR-NH2, derived from the protease-activated receptor-1 (PAR1), is a selective PAR1 agonist with an EC50 of 1.9 μM.
OUL35 Chemical Structure
BCP37863 OUL35 6336-34-1
OUL35 is a small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death.
BGP-15 dihydrochloride Chemical Structure
BCP24844 BGP-15 dihydrochloride 66611-37-8
BGP-15 is a PARP inhibitor, with an IC50 and a Ki of 120 and 57 μM, respectively.
RBN-2397 Chemical Structure
BCP33764 RBN-2397 2381037-82-5
RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM).
Rucaparib camsylate Chemical Structure
BCP25678 Rucaparib camsylate 1327258-57-0
Rucaparib camsylate is a camphorsulfonate salt obtained by reaction of rucaparib with one molar equivalent of (1S,4R)-camphorsulfonic acid. It is an inhibitor of poly (ADP-ribose) polymerase and is used as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.
ITK7 Chemical Structure
BCP33173 ITK7 ITK7
PARP11 inhibitor ITK7 (ITK7) is a potent and selective PARP11 inhibitor with IC50 of 14 nM, displays >200-fold selectivity over other PARPs.
GeA-69 Chemical Structure
BCP31007 GeA-69 2143475-98-1
GeA-69 is a novel selective allosteric inhibitor targeting macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14.
BSI-401 Chemical Structure
BCP27642 BSI-401 142404-10-2
BSI-401 is a novel PARP-1 inhibitor with both oral bioavailability and strong antitumor potency.
RK-287107 Chemical Structure
BCP30401 RK-287107 2171386-10-8
RK-287107 is a potent TNKS/TNKS2 inhibitor (IC50 = 14.4 nM) with >7000-fold selectivity against the PARP1 enzyme, which inhibits WNT-responsive TCF reporter activity and proliferation of human colorectal cancer cell line COLO-320DM.
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