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PI3K

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PI3K

Chemical Structure Cat. No. Product Name CAS No.
SRX3207 Chemical Structure
BCP40266 SRX3207 2254693-15-5
SRX3207 is an orally active dual inhibitor of Syk-PI3K with IC50 of 39.9 nM, 31200 nM, 3070 nM, 3070 nM, 244 nM, 388 nM, 9790 nM for Syk, Zap70, BRD41, BRD42, PI3K alpha, PI3K delta, PI3K gamma, respectively.
IPI-3063 Chemical Structure
BCP39855 IPI-3063 1425043-73-7
IPI-3063 is a potent and selective phosphoinoside-3-kinase (PI3K) p110δ inhibitor. IPI-3063 was shown to inhibit mouse B cell proliferation, survival, and plasmablast differentiation, and also inhibit human B cell proliferation in vitro.
Nemiralisib Chemical Structure
BCP38658 Nemiralisib 1254036-71-9
Nemiralisib, also known as GSK2269557, is a highly potent and selective inhaled PI3Kδ inhibitor for the treatment of COPD.
SAR405 R enantiomer Chemical Structure
BCP37991 SAR405 R enantiomer 1946010-79-2
SAR405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with MTOR inhibition in tumor cells.
CGS 15943 Chemical Structure
BCP37843 CGS 15943 104615-18-1
CGS 15943 is a potent adenosine receptor antagonist (Ki values are 3.5, 4.2, 16 and 51 nM for human A1, A2A, A2B and A3 receptors respectively).
Zandelisib Chemical Structure
BCP36800 Zandelisib 1401436-95-0
Zandelisib is a phosphatidylinositol 3-kinase (PI3K) inhibitor, and antineoplastic.
PI-103 Hydrochloride Chemical Structure
BCP36117 PI-103 Hydrochloride 371935-79-4
PI-103 Hydrochloride is a dual PI3K and mTOR inhibitor with IC50s of 8 nM, 88 nM, 48 nM, 150 nM, 20 nM, and 83 nM for p110α, p110β, p110δ, p110γ, mTORC1, and mTORC2. PI-103 Hydrochloride also inhibits DNA-PK with an IC50 of 2 nM. PI-103 Hydrochloride induces autophagy.
Recilisib sodium Chemical Structure
BCP35048 Recilisib sodium 922139-31-9
Recilisib is a radioprotectant, which can activate AKT, PI3K activities in cells.
Alpelisib hydrochloride Chemical Structure
BCP34729 Alpelisib hydrochloride 1584128-91-5
Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively.
Parsaclisib Chemical Structure
BCP33523 Parsaclisib 1426698-88-5
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
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